The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain
نویسندگان
چکیده
منابع مشابه
∆FosB differentially modulates nucleus accumbens direct and indirect pathway function.
Synaptic modifications in nucleus accumbens (NAc) medium spiny neurons (MSNs) play a key role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction. NAc MSNs participate in two parallel circuits, direct and indirect pathways that subserve distinct behavioral functions. Modification of NAc MSN synapses may occur in part via changes in ...
متن کاملChange in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain.
Neuropathic pain is the most difficult type of pain to control, and patients lose their motivation for the purposive pursuit with a decrease in their quality of life. Using a functional magnetic resonance imaging analysis, we demonstrated that blood oxygenation level-dependent signal intensity was increased in the ipsilateral nucleus accumbens (N.Acc.) following peripheral nerve injury. microRN...
متن کاملThe Effect of Nitric Oxide Microinjection in Nucleus Accumbens Shell on Morphine Withdrawal Signs in Male Rats
Introduction: This study was performed to evaluate the effects of intra-nucleus accumbens shell microinjection of Larginine (NO precursor) and L-NAME (nitric oxide synthase (NOS) inhibitor) on morphine withdrawal signs in male rats. Method: Rats were anaesthetized with a combination of ketamine and xylazine, and placed in stereotaxic apparatus, and a guide cannula was inserted into nucleus accu...
متن کاملPS136. Time-dependent alteration of reward-induced dopamine release in the nucleus accumbens of the neuropathic pain model rats.
In recent studies we have shown that the tryptophan (TRP) depletion model of depression previously validated in male rats is paroxetine-resistant in females (Franklin et al. 2015). In this model, we found that secretion of the mineralocorticoid hormone aldosterone increased after 4 days of TRP depletion and surprisingly prior to corticosterone enhancement. The study aim was to investigate the e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2015
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.4199